Mardock City isn’t an innocent place. Rune Ballot sells her body to earn some money. Her life was ordinal until she met a crazy gambler Shell Septinous. Shell used Rune’s services and decided to kill her. Her life was hanging by a thread, but luckily Dr Easter noticed the victim and turned her into a cyborg. A new Rune follows a small mouse robot to adjust to the current circumstances. The creator supplied Rune with comprehensive technologies that protect Rune from any harm or Shell’s aggression. When Shell realizes Ballot is alive he plans to finish her not to make Rune witness against him.